Focused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
The SNARE complex enables the fusion of synaptic vesicles with presynaptic membrane via a zippering process that is modulated by the protein complexin, though the precise mechanism remains unclear. Here, the authors used magnetic tweezers to show how complexin prepares a SNARE complex for fusion und...
Saved in:
Main Authors: | Min Ju Shon, Haesoo Kim, Tae-Young Yoon |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/38af0186841e42e99dfb6e424b4a0c3b |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
by: Nicholas A. Courtney, et al.
Published: (2019) -
Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes
by: Changwon Kim, et al.
Published: (2021) -
Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis.
by: Pei-Shiue J Tsai, et al.
Published: (2012) -
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
by: Kirill Grushin, et al.
Published: (2019) -
Patch clamp-assisted single neuron lipidomics
by: Collin B. Merrill, et al.
Published: (2017)