Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively targets BCL-xL/2-dependent leukaemia cells.
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Nature Portfolio
2021
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oai:doaj.org-article:38d97353bbbf41e4aa6eb4a5907c3bd42021-11-28T12:33:21ZDevelopment of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,10.1038/s41467-021-27210-x2041-1723https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27210-xhttps://doaj.org/toc/2041-1723Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively targets BCL-xL/2-dependent leukaemia cells.Dongwen LvPratik PalXingui LiuYannan JiaDinesh ThummuriPeiyi ZhangWanyi HuJing PeiQi ZhangShuo ZhouSajid KhanXuan ZhangNan HuaQingping YangSebastian ArangoWeizhou ZhangDigant NayakShaun K. OlsenSusan T. WeintraubRobert HromasMarina KonoplevaYaxia YuanGuangrong ZhengDaohong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dongwen Lv Pratik Pal Xingui Liu Yannan Jia Dinesh Thummuri Peiyi Zhang Wanyi Hu Jing Pei Qi Zhang Shuo Zhou Sajid Khan Xuan Zhang Nan Hua Qingping Yang Sebastian Arango Weizhou Zhang Digant Nayak Shaun K. Olsen Susan T. Weintraub Robert Hromas Marina Konopleva Yaxia Yuan Guangrong Zheng Daohong Zhou Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| description |
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively targets BCL-xL/2-dependent leukaemia cells. |
| format |
article |
| author |
Dongwen Lv Pratik Pal Xingui Liu Yannan Jia Dinesh Thummuri Peiyi Zhang Wanyi Hu Jing Pei Qi Zhang Shuo Zhou Sajid Khan Xuan Zhang Nan Hua Qingping Yang Sebastian Arango Weizhou Zhang Digant Nayak Shaun K. Olsen Susan T. Weintraub Robert Hromas Marina Konopleva Yaxia Yuan Guangrong Zheng Daohong Zhou |
| author_facet |
Dongwen Lv Pratik Pal Xingui Liu Yannan Jia Dinesh Thummuri Peiyi Zhang Wanyi Hu Jing Pei Qi Zhang Shuo Zhou Sajid Khan Xuan Zhang Nan Hua Qingping Yang Sebastian Arango Weizhou Zhang Digant Nayak Shaun K. Olsen Susan T. Weintraub Robert Hromas Marina Konopleva Yaxia Yuan Guangrong Zheng Daohong Zhou |
| author_sort |
Dongwen Lv |
| title |
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| title_short |
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| title_full |
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| title_fullStr |
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| title_full_unstemmed |
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity, |
| title_sort |
development of a bcl-xl and bcl-2 dual degrader with improved anti-leukemic activity, |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd4 |
| work_keys_str_mv |
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