Change in Cofactor Specificity of Oxidoreductases by Adaptive Evolution of an <named-content content-type="genus-species">Escherichia coli</named-content> NADPH-Auxotrophic Strain

Change in Cofactor Specificity of Oxidoreductases by Adaptive Evolution of an <named-content content-type="genus-species">Escherichia coli</named-content> NADPH-Auxotrophic Strain

ABSTRACT The nicotinamide cofactor specificity of enzymes plays a key role in regulating metabolic processes and attaining cellular homeostasis. Multiple studies have used enzyme engineering tools or a directed evolution approach to switch the cofactor preference of specific oxidoreductases. However...

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Bibliographic Details
Main Authors: Madeleine Bouzon, Volker Döring, Ivan Dubois, Anne Berger, Gabriele M. M. Stoffel, Liliana Calzadiaz Ramirez, Sophia N. Meyer, Marion Fouré, David Roche, Alain Perret, Tobias J. Erb, Arren Bar-Even, Steffen N. Lindner
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
evolution
NADPH
metabolism
NADPH-auxotrophic strain
ALE
oxidoreductases
Microbiology
QR1-502
Online Access:https://doaj.org/article/38fd0ac8befb44b2b7318eb60777cb4e
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https://doaj.org/article/38fd0ac8befb44b2b7318eb60777cb4e

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