An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby contro...

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Autores principales: Jae-Kyung Nam, A-Ram Kim, Seo-Hyun Choi, Ji-Hee Kim, Kyu Jin Choi, Seulki Cho, Jae Won Lee, Hyun-Jai Cho, Yoo-Wook Kwon, Jaeho Cho, Kwang Seok Kim, Joon Kim, Hae-June Lee, Tae Sup Lee, Sangwoo Bae, Hyo Jeong Hong, Yoon-Jin Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/390ba1c3b7ef40a4a2315adde73d9f10
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spelling oai:doaj.org-article:390ba1c3b7ef40a4a2315adde73d9f102021-12-02T15:02:55ZAn antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage10.1038/s41467-021-23478-12041-1723https://doaj.org/article/390ba1c3b7ef40a4a2315adde73d9f102021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23478-1https://doaj.org/toc/2041-1723Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby controlling vascular DNA damage and preventing cardiotoxicity.Jae-Kyung NamA-Ram KimSeo-Hyun ChoiJi-Hee KimKyu Jin ChoiSeulki ChoJae Won LeeHyun-Jai ChoYoo-Wook KwonJaeho ChoKwang Seok KimJoon KimHae-June LeeTae Sup LeeSangwoo BaeHyo Jeong HongYoon-Jin LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jae-Kyung Nam
A-Ram Kim
Seo-Hyun Choi
Ji-Hee Kim
Kyu Jin Choi
Seulki Cho
Jae Won Lee
Hyun-Jai Cho
Yoo-Wook Kwon
Jaeho Cho
Kwang Seok Kim
Joon Kim
Hae-June Lee
Tae Sup Lee
Sangwoo Bae
Hyo Jeong Hong
Yoon-Jin Lee
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
description Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby controlling vascular DNA damage and preventing cardiotoxicity.
format article
author Jae-Kyung Nam
A-Ram Kim
Seo-Hyun Choi
Ji-Hee Kim
Kyu Jin Choi
Seulki Cho
Jae Won Lee
Hyun-Jai Cho
Yoo-Wook Kwon
Jaeho Cho
Kwang Seok Kim
Joon Kim
Hae-June Lee
Tae Sup Lee
Sangwoo Bae
Hyo Jeong Hong
Yoon-Jin Lee
author_facet Jae-Kyung Nam
A-Ram Kim
Seo-Hyun Choi
Ji-Hee Kim
Kyu Jin Choi
Seulki Cho
Jae Won Lee
Hyun-Jai Cho
Yoo-Wook Kwon
Jaeho Cho
Kwang Seok Kim
Joon Kim
Hae-June Lee
Tae Sup Lee
Sangwoo Bae
Hyo Jeong Hong
Yoon-Jin Lee
author_sort Jae-Kyung Nam
title An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
title_short An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
title_full An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
title_fullStr An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
title_full_unstemmed An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
title_sort antibody against l1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent dna damage
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/390ba1c3b7ef40a4a2315adde73d9f10
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