TMT-based quantitative proteomics analysis reveals the attenuated replication mechanism of Newcastle disease virus caused by nuclear localization signal mutation in viral matrix protein

Nuclear localization of cytoplasmic RNA virus proteins mediated by intrinsic nuclear localization signal (NLS) plays essential roles in successful virus replication. We previously reported that NLS mutation in the matrix (M) protein obviously attenuates the replication and pathogenicity of Newcastle...

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Autores principales: Zhiqiang Duan, Chao Yuan, Yifan Han, Lei Zhou, Jiafu Zhao, Yong Ruan, Jiaqi Chen, Mengmeng Ni, Xinqin Ji
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2020
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tmt
Acceso en línea:https://doaj.org/article/39168f0e1b27410e8d645f0c2dea02d4
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