Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

Abstract Resistance-Nodulation-cell Division (RND) transporters AcrB and AcrD of Escherichia coli expel a wide range of substrates out of the cell in conjunction with AcrA and TolC, contributing to the onset of bacterial multidrug resistance. Despite sharing an overall sequence identity of ~66% (sim...

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Autores principales: Venkata Krishnan Ramaswamy, Attilio V. Vargiu, Giuliano Malloci, Jürg Dreier, Paolo Ruggerone
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/392930ee1eca422298bd285496cace51
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