Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicr...

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Autores principales:	Hao Yu, Patricia Dranchak, Zhiru Li, Ryan MacArthur, Matthew S. Munson, Nurjahan Mehzabeen, Nathan J. Baird, Kevin P. Battalie, David Ross, Scott Lovell, Clotilde K. S. Carlow, Hiroaki Suga, James Inglese
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39345025d3334fe096b7ce4373349fee
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spelling	oai:doaj.org-article:39345025d3334fe096b7ce4373349fee2021-12-02T15:38:32ZMacrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases10.1038/ncomms149322041-1723https://doaj.org/article/39345025d3334fe096b7ce4373349fee2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14932https://doaj.org/toc/2041-1723River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.Hao YuPatricia DranchakZhiru LiRyan MacArthurMatthew S. MunsonNurjahan MehzabeenNathan J. BairdKevin P. BattalieDavid RossScott LovellClotilde K. S. CarlowHiroaki SugaJames IngleseNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Yu Patricia Dranchak Zhiru Li Ryan MacArthur Matthew S. Munson Nurjahan Mehzabeen Nathan J. Baird Kevin P. Battalie David Ross Scott Lovell Clotilde K. S. Carlow Hiroaki Suga James Inglese Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
description	River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.
format	article
author	Hao Yu Patricia Dranchak Zhiru Li Ryan MacArthur Matthew S. Munson Nurjahan Mehzabeen Nathan J. Baird Kevin P. Battalie David Ross Scott Lovell Clotilde K. S. Carlow Hiroaki Suga James Inglese
author_facet	Hao Yu Patricia Dranchak Zhiru Li Ryan MacArthur Matthew S. Munson Nurjahan Mehzabeen Nathan J. Baird Kevin P. Battalie David Ross Scott Lovell Clotilde K. S. Carlow Hiroaki Suga James Inglese
author_sort	Hao Yu
title	Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
title_short	Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
title_full	Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
title_fullStr	Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
title_full_unstemmed	Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
title_sort	macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/39345025d3334fe096b7ce4373349fee
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Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

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