Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells

Indonesian Black Garlic (IBG) ethanol extracts is a new type of fresh garlic product, produced at high temperature and humidity. IBG has active antioxidant activity. Thy study aimed to evaluate the anti-inflammatory actions of IBG in RAW 264.7 macrophage cells. The cells were cultures and treated wi...

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Autores principales:	Laurentia Adinda Pratidina, Seong Gu Hwang, Novita Wijayanti
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	indonesian black garlic anti-inflammatory raw 264.7 macrophage cells Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3936fe2a4f3140ae857477ae838b73c1
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spelling	oai:doaj.org-article:3936fe2a4f3140ae857477ae838b73c12021-11-15T06:08:46ZAnti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells2338-94272338-948610.22146/ijp.1658https://doaj.org/article/3936fe2a4f3140ae857477ae838b73c12021-06-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1658https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Indonesian Black Garlic (IBG) ethanol extracts is a new type of fresh garlic product, produced at high temperature and humidity. IBG has active antioxidant activity. Thy study aimed to evaluate the anti-inflammatory actions of IBG in RAW 264.7 macrophage cells. The cells were cultures and treated with different concentrations of IBG (50 to 1000 mg/mL). The cell counting kit-8 assay showed that IBG was not toxic up to 400 mg/mL. IBG significantly decreased the expression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophage cells. Futhermore, IBG is shown to inhibit pro-inflammatory cytokines, this is evident from the decreased expressions of iNOS, COX-2, IL-6, NF-kB, and TNF-α in mRNA expressions and also on protein level. The results suggest that IBG can be used to prevent or cure inflammation-related diseases.Laurentia Adinda PratidinaSeong Gu HwangNovita WijayantiUniversitas Gadjah Madaarticleindonesian black garlicanti-inflammatoryraw 264.7 macrophage cellsPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 201-208 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	indonesian black garlic anti-inflammatory raw 264.7 macrophage cells Pharmacy and materia medica RS1-441
spellingShingle	indonesian black garlic anti-inflammatory raw 264.7 macrophage cells Pharmacy and materia medica RS1-441 Laurentia Adinda Pratidina Seong Gu Hwang Novita Wijayanti Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
description	Indonesian Black Garlic (IBG) ethanol extracts is a new type of fresh garlic product, produced at high temperature and humidity. IBG has active antioxidant activity. Thy study aimed to evaluate the anti-inflammatory actions of IBG in RAW 264.7 macrophage cells. The cells were cultures and treated with different concentrations of IBG (50 to 1000 mg/mL). The cell counting kit-8 assay showed that IBG was not toxic up to 400 mg/mL. IBG significantly decreased the expression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophage cells. Futhermore, IBG is shown to inhibit pro-inflammatory cytokines, this is evident from the decreased expressions of iNOS, COX-2, IL-6, NF-kB, and TNF-α in mRNA expressions and also on protein level. The results suggest that IBG can be used to prevent or cure inflammation-related diseases.
format	article
author	Laurentia Adinda Pratidina Seong Gu Hwang Novita Wijayanti
author_facet	Laurentia Adinda Pratidina Seong Gu Hwang Novita Wijayanti
author_sort	Laurentia Adinda Pratidina
title	Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
title_short	Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
title_full	Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
title_fullStr	Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
title_full_unstemmed	Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells
title_sort	anti-inflammatory action of indonesian black garlic (ibg) ethanol extracts in lps-stimulated raw 264.7 macrophage cells
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/3936fe2a4f3140ae857477ae838b73c1
work_keys_str_mv	AT laurentiaadindapratidina antiinflammatoryactionofindonesianblackgarlicibgethanolextractsinlpsstimulatedraw2647macrophagecells AT seongguhwang antiinflammatoryactionofindonesianblackgarlicibgethanolextractsinlpsstimulatedraw2647macrophagecells AT novitawijayanti antiinflammatoryactionofindonesianblackgarlicibgethanolextractsinlpsstimulatedraw2647macrophagecells
_version_	1718428545093468160

Anti-Inflammatory Action of Indonesian Black Garlic (IBG) Ethanol Extracts in LPS-stimulated RAW 264.7 Macrophage Cells

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