BAP1 methylation: a prognostic marker of uveal melanoma metastasis

Abstract Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous...

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Autores principales:	Mathieu F. Bakhoum, Ellis J. Curtis, Michael H. Goldbaum, Paul S. Mischel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/395a1f5c7d9d4efd8442138aedade9e3
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spelling	oai:doaj.org-article:395a1f5c7d9d4efd8442138aedade9e32021-12-02T18:51:13ZBAP1 methylation: a prognostic marker of uveal melanoma metastasis10.1038/s41698-021-00226-82397-768Xhttps://doaj.org/article/395a1f5c7d9d4efd8442138aedade9e32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00226-8https://doaj.org/toc/2397-768XAbstract Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.Mathieu F. BakhoumEllis J. CurtisMichael H. GoldbaumPaul S. MischelNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mathieu F. Bakhoum Ellis J. Curtis Michael H. Goldbaum Paul S. Mischel BAP1 methylation: a prognostic marker of uveal melanoma metastasis
description	Abstract Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.
format	article
author	Mathieu F. Bakhoum Ellis J. Curtis Michael H. Goldbaum Paul S. Mischel
author_facet	Mathieu F. Bakhoum Ellis J. Curtis Michael H. Goldbaum Paul S. Mischel
author_sort	Mathieu F. Bakhoum
title	BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_short	BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_full	BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_fullStr	BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_full_unstemmed	BAP1 methylation: a prognostic marker of uveal melanoma metastasis
title_sort	bap1 methylation: a prognostic marker of uveal melanoma metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/395a1f5c7d9d4efd8442138aedade9e3
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BAP1 methylation: a prognostic marker of uveal melanoma metastasis

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