ALK and IGF-1R as independent targets in crizotinib resistant lung cancer

Abstract ALK positive non-small cell lung cancer is highly responsive to ALK inhibitors such as crizotinib, but drug resistance typically develops within a year of treatment. In this study we investigated whether IGF-1R is an independent druggable target in ALK-positive lung cancer cells. We confirm...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Christabel Wilson, Mhairi Nimick, Hayley Nehoff, John C. Ashton
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/398999e043dc426f9106b6eb7c119b5d
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