Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

Abstract TNFα is a homotrimeric pro-inflammatory cytokine, whose direct targeting by protein biotherapies has been an undeniable success for the treatment of chronic inflammatory diseases. Despite many efforts, no orally active drug targeting TNFα has been identified so far. In the present work, we...

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Autores principales: Hadley Mouhsine, Hélène Guillemain, Gabriel Moreau, Najla Fourati, Chouki Zerrouki, Bruno Baron, Lucille Desallais, Patrick Gizzi, Nesrine Ben Nasr, Julie Perrier, Rojo Ratsimandresy, Jean-Louis Spadoni, Hervé Do, Patrick England, Matthieu Montes, Jean-François Zagury
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/39a52ba9f13047d9bc2fffd31ecd4d79
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https://doaj.org/article/39a52ba9f13047d9bc2fffd31ecd4d79

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