Engineering human pluripotent stem cells into a functional skeletal muscle tissue

The generation of functional skeletal muscle tissue from human pluripotent stem cells has not been reported. Here, the authors describe engineering of contractile skeletal muscle bundles in culture, which become vascularized and maintain functionality when transplanted into mice.

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Autores principales:	Lingjun Rao, Ying Qian, Alastair Khodabukus, Thomas Ribar, Nenad Bursac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39c072b874824259bdaae64f626b75e9
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spelling	oai:doaj.org-article:39c072b874824259bdaae64f626b75e92021-12-02T15:34:41ZEngineering human pluripotent stem cells into a functional skeletal muscle tissue10.1038/s41467-017-02636-42041-1723https://doaj.org/article/39c072b874824259bdaae64f626b75e92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02636-4https://doaj.org/toc/2041-1723The generation of functional skeletal muscle tissue from human pluripotent stem cells has not been reported. Here, the authors describe engineering of contractile skeletal muscle bundles in culture, which become vascularized and maintain functionality when transplanted into mice.Lingjun RaoYing QianAlastair KhodabukusThomas RibarNenad BursacNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingjun Rao Ying Qian Alastair Khodabukus Thomas Ribar Nenad Bursac Engineering human pluripotent stem cells into a functional skeletal muscle tissue
description	The generation of functional skeletal muscle tissue from human pluripotent stem cells has not been reported. Here, the authors describe engineering of contractile skeletal muscle bundles in culture, which become vascularized and maintain functionality when transplanted into mice.
format	article
author	Lingjun Rao Ying Qian Alastair Khodabukus Thomas Ribar Nenad Bursac
author_facet	Lingjun Rao Ying Qian Alastair Khodabukus Thomas Ribar Nenad Bursac
author_sort	Lingjun Rao
title	Engineering human pluripotent stem cells into a functional skeletal muscle tissue
title_short	Engineering human pluripotent stem cells into a functional skeletal muscle tissue
title_full	Engineering human pluripotent stem cells into a functional skeletal muscle tissue
title_fullStr	Engineering human pluripotent stem cells into a functional skeletal muscle tissue
title_full_unstemmed	Engineering human pluripotent stem cells into a functional skeletal muscle tissue
title_sort	engineering human pluripotent stem cells into a functional skeletal muscle tissue
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/39c072b874824259bdaae64f626b75e9
work_keys_str_mv	AT lingjunrao engineeringhumanpluripotentstemcellsintoafunctionalskeletalmuscletissue AT yingqian engineeringhumanpluripotentstemcellsintoafunctionalskeletalmuscletissue AT alastairkhodabukus engineeringhumanpluripotentstemcellsintoafunctionalskeletalmuscletissue AT thomasribar engineeringhumanpluripotentstemcellsintoafunctionalskeletalmuscletissue AT nenadbursac engineeringhumanpluripotentstemcellsintoafunctionalskeletalmuscletissue
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Engineering human pluripotent stem cells into a functional skeletal muscle tissue

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