Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ubiquitination of Insig-2, stabilising Insig-2 and reducin...

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Autores principales: Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/39cecb221deb45dc9f684b805dec75f2
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