Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ubiquitination of Insig-2, stabilising Insig-2 and reducin...

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Autores principales:	Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39cecb221deb45dc9f684b805dec75f2
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spelling	oai:doaj.org-article:39cecb221deb45dc9f684b805dec75f22021-12-02T14:41:15ZCompetitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-210.1038/s41467-019-14231-w2041-1723https://doaj.org/article/39cecb221deb45dc9f684b805dec75f22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14231-whttps://doaj.org/toc/2041-1723The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ubiquitination of Insig-2, stabilising Insig-2 and reducing lipid biosynthesis.Zhang-Sen ZhouMei-Xin LiJie LiuHengwu JiaoJing-Ming XiaXiong-Jie ShiHuabin ZhaoLiping ChuJingrong LiuWei QiJie LuoBao-Liang SongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhang-Sen Zhou Mei-Xin Li Jie Liu Hengwu Jiao Jing-Ming Xia Xiong-Jie Shi Huabin Zhao Liping Chu Jingrong Liu Wei Qi Jie Luo Bao-Liang Song Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
description	The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ubiquitination of Insig-2, stabilising Insig-2 and reducing lipid biosynthesis.
format	article
author	Zhang-Sen Zhou Mei-Xin Li Jie Liu Hengwu Jiao Jing-Ming Xia Xiong-Jie Shi Huabin Zhao Liping Chu Jingrong Liu Wei Qi Jie Luo Bao-Liang Song
author_facet	Zhang-Sen Zhou Mei-Xin Li Jie Liu Hengwu Jiao Jing-Ming Xia Xiong-Jie Shi Huabin Zhao Liping Chu Jingrong Liu Wei Qi Jie Luo Bao-Liang Song
author_sort	Zhang-Sen Zhou
title	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
title_short	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
title_full	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
title_fullStr	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
title_full_unstemmed	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
title_sort	competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of insig-2
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/39cecb221deb45dc9f684b805dec75f2
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Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

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