A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

Abstract The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines based on the original Wuhan sequence have been shown to be effective at preventing COVID-19, their efficacy is likely to b...

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Autores principales:	Mitch Brinkkemper, Philip J. M. Brouwer, Pauline Maisonnasse, Marloes Grobben, Tom G. Caniels, Meliawati Poniman, Judith A. Burger, Ilja Bontjer, Melissa Oomen, Joey H. Bouhuijs, Cynthia A. van der Linden, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Roger Le Grand, Rogier W. Sanders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/39e9afe868e64efa8901980882397e7e
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spelling	oai:doaj.org-article:39e9afe868e64efa8901980882397e7e2021-12-05T12:05:33ZA third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern10.1038/s41541-021-00411-72059-0105https://doaj.org/article/39e9afe868e64efa8901980882397e7e2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00411-7https://doaj.org/toc/2059-0105Abstract The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines based on the original Wuhan sequence have been shown to be effective at preventing COVID-19, their efficacy is likely to be decreased against more neutralization-resistant variants-of-concern (VOC), in particular, the Beta variant originating in South Africa. We assessed, in mice, rabbits, and non-human primates, whether a third vaccination with experimental Wuhan-based Spike vaccines could alleviate this problem. Our data show that a third immunization improves neutralizing antibody titers against the variants-of-concern, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). After three vaccinations, the level of neutralization against Beta was similar to the level of neutralization against the original strain after two vaccinations, suggesting that simply providing a third immunization could nullify the reduced activity of current vaccines against VOC.Mitch BrinkkemperPhilip J. M. BrouwerPauline MaisonnasseMarloes GrobbenTom G. CanielsMeliawati PonimanJudith A. BurgerIlja BontjerMelissa OomenJoey H. BouhuijsCynthia A. van der LindenJulien VillaudyYme U. van der VeldenKwinten SliepenMarit J. van GilsRoger Le GrandRogier W. SandersNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mitch Brinkkemper Philip J. M. Brouwer Pauline Maisonnasse Marloes Grobben Tom G. Caniels Meliawati Poniman Judith A. Burger Ilja Bontjer Melissa Oomen Joey H. Bouhuijs Cynthia A. van der Linden Julien Villaudy Yme U. van der Velden Kwinten Sliepen Marit J. van Gils Roger Le Grand Rogier W. Sanders A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
description	Abstract The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines based on the original Wuhan sequence have been shown to be effective at preventing COVID-19, their efficacy is likely to be decreased against more neutralization-resistant variants-of-concern (VOC), in particular, the Beta variant originating in South Africa. We assessed, in mice, rabbits, and non-human primates, whether a third vaccination with experimental Wuhan-based Spike vaccines could alleviate this problem. Our data show that a third immunization improves neutralizing antibody titers against the variants-of-concern, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). After three vaccinations, the level of neutralization against Beta was similar to the level of neutralization against the original strain after two vaccinations, suggesting that simply providing a third immunization could nullify the reduced activity of current vaccines against VOC.
format	article
author	Mitch Brinkkemper Philip J. M. Brouwer Pauline Maisonnasse Marloes Grobben Tom G. Caniels Meliawati Poniman Judith A. Burger Ilja Bontjer Melissa Oomen Joey H. Bouhuijs Cynthia A. van der Linden Julien Villaudy Yme U. van der Velden Kwinten Sliepen Marit J. van Gils Roger Le Grand Rogier W. Sanders
author_facet	Mitch Brinkkemper Philip J. M. Brouwer Pauline Maisonnasse Marloes Grobben Tom G. Caniels Meliawati Poniman Judith A. Burger Ilja Bontjer Melissa Oomen Joey H. Bouhuijs Cynthia A. van der Linden Julien Villaudy Yme U. van der Velden Kwinten Sliepen Marit J. van Gils Roger Le Grand Rogier W. Sanders
author_sort	Mitch Brinkkemper
title	A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
title_short	A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
title_full	A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
title_fullStr	A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
title_full_unstemmed	A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
title_sort	third sars-cov-2 spike vaccination improves neutralization of variants-of-concern
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/39e9afe868e64efa8901980882397e7e
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A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

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