Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncopro...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
APOBEC3B
RB/E2F pathway
polyomavirus
virus evolution
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e

Ejemplares similares