Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncopro...

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Bibliographic Details
Main Authors: Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
APOBEC3B
RB/E2F pathway
polyomavirus
virus evolution
Microbiology
QR1-502
Online Access:https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e
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https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e

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