Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

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Polyomavirus T Antigen Induces <italic toggle="yes">APOBEC3B</italic> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncopro...

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Autores principales:	Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	APOBEC3B RB/E2F pathway polyomavirus virus evolution Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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