Reovirus directly engages integrin to recruit clathrin for entry into host cells

Reovirus directly engages integrin to recruit clathrin for entry into host cells

Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin...

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Bibliographic Details
Main Authors: Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Mégane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
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Summary:Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin recruitment to cell-bound reovirus.

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