BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is overexpressed and acts largely independently of th...

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Autores principales:	Dominik Laubscher, Berkley E. Gryder, Benjamin D. Sunkel, Thorkell Andresson, Marco Wachtel, Sudipto Das, Bernd Roschitzki, Witold Wolski, Xiaoli S. Wu, Hsien-Chao Chou, Young K. Song, Chaoyu Wang, Jun S. Wei, Meng Wang, Xinyu Wen, Quy Ai Ngo, Joana G. Marques, Christopher R. Vakoc, Beat W. Schäfer, Benjamin Z. Stanton, Javed Khan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b538
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spelling	oai:doaj.org-article:3a3e0d79c30a410f82f8195b27c0b5382021-11-28T12:31:27ZBAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma10.1038/s41467-021-27176-w2041-1723https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b5382021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27176-whttps://doaj.org/toc/2041-1723Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is overexpressed and acts largely independently of the PAX3-FOXO1 chimera on chromatin to result in a myogenic differentiation blockade in this malignancy.Dominik LaubscherBerkley E. GryderBenjamin D. SunkelThorkell AndressonMarco WachtelSudipto DasBernd RoschitzkiWitold WolskiXiaoli S. WuHsien-Chao ChouYoung K. SongChaoyu WangJun S. WeiMeng WangXinyu WenQuy Ai NgoJoana G. MarquesChristopher R. VakocBeat W. SchäferBenjamin Z. StantonJaved KhanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominik Laubscher Berkley E. Gryder Benjamin D. Sunkel Thorkell Andresson Marco Wachtel Sudipto Das Bernd Roschitzki Witold Wolski Xiaoli S. Wu Hsien-Chao Chou Young K. Song Chaoyu Wang Jun S. Wei Meng Wang Xinyu Wen Quy Ai Ngo Joana G. Marques Christopher R. Vakoc Beat W. Schäfer Benjamin Z. Stanton Javed Khan BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
description	Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is overexpressed and acts largely independently of the PAX3-FOXO1 chimera on chromatin to result in a myogenic differentiation blockade in this malignancy.
format	article
author	Dominik Laubscher Berkley E. Gryder Benjamin D. Sunkel Thorkell Andresson Marco Wachtel Sudipto Das Bernd Roschitzki Witold Wolski Xiaoli S. Wu Hsien-Chao Chou Young K. Song Chaoyu Wang Jun S. Wei Meng Wang Xinyu Wen Quy Ai Ngo Joana G. Marques Christopher R. Vakoc Beat W. Schäfer Benjamin Z. Stanton Javed Khan
author_facet	Dominik Laubscher Berkley E. Gryder Benjamin D. Sunkel Thorkell Andresson Marco Wachtel Sudipto Das Bernd Roschitzki Witold Wolski Xiaoli S. Wu Hsien-Chao Chou Young K. Song Chaoyu Wang Jun S. Wei Meng Wang Xinyu Wen Quy Ai Ngo Joana G. Marques Christopher R. Vakoc Beat W. Schäfer Benjamin Z. Stanton Javed Khan
author_sort	Dominik Laubscher
title	BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
title_short	BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
title_full	BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
title_fullStr	BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
title_full_unstemmed	BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
title_sort	baf complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b538
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BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma

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