Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3a4e763ec2524631b9b17f9c947198cb
record_format	dspace
spelling	oai:doaj.org-article:3a4e763ec2524631b9b17f9c947198cb2021-12-02T17:06:06ZMaternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II10.1038/ncomms153462041-1723https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15346https://doaj.org/toc/2041-1723Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.Ibtissem NabtiRosanna GrimesHema SarnaPetros MarangosJohn CarrollNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ibtissem Nabti Rosanna Grimes Hema Sarna Petros Marangos John Carroll Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
description	Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.
format	article
author	Ibtissem Nabti Rosanna Grimes Hema Sarna Petros Marangos John Carroll
author_facet	Ibtissem Nabti Rosanna Grimes Hema Sarna Petros Marangos John Carroll
author_sort	Ibtissem Nabti
title	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
title_short	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
title_full	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
title_fullStr	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
title_full_unstemmed	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
title_sort	maternal age-dependent apc/c-mediated decrease in securin causes premature sister chromatid separation in meiosis ii
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb
work_keys_str_mv	AT ibtissemnabti maternalagedependentapccmediateddecreaseinsecurincausesprematuresisterchromatidseparationinmeiosisii AT rosannagrimes maternalagedependentapccmediateddecreaseinsecurincausesprematuresisterchromatidseparationinmeiosisii AT hemasarna maternalagedependentapccmediateddecreaseinsecurincausesprematuresisterchromatidseparationinmeiosisii AT petrosmarangos maternalagedependentapccmediateddecreaseinsecurincausesprematuresisterchromatidseparationinmeiosisii AT johncarroll maternalagedependentapccmediateddecreaseinsecurincausesprematuresisterchromatidseparationinmeiosisii
_version_	1718381723665825792

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Ejemplares similares