Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.

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Autores principales: Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb
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