Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|