Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance.
The epidermal growth factor receptor inhibitor cetuximab is the only oncogene-targeted agent that has been FDA approved for the treatment of head and neck squamous cell carcinoma (HNSCC). Currently, there are no biomarkers used in the clinic to predict which HNSCC tumors will respond to cetuximab, a...
Guardado en:
Autores principales: | Rachel A O'Keefe, Neil E Bhola, David S Lee, Daniel E Johnson, Jennifer R Grandis |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3a82731b4be942d993e1bf5b570f6167 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients
por: Steven M. Bray, et al.
Publicado: (2019) -
Interleukin‐33 as an early predictor of cetuximab treatment efficacy in patients with colorectal cancer
por: Xujun Zhang, et al.
Publicado: (2021) -
Low-grade metabolic acidosis as a driver of insulin resistance
por: James J DiNicolantonio, et al.
Publicado: (2021) -
Enhancer RNA Profiling in Smoking and HPV Associated HNSCC Reveals Associations to Key Oncogenes
por: Neil Shende, et al.
Publicado: (2021) -
Tracking acquired antibiotic resistance in commensal bacteria of Galápagos land iguanas: no man, no resistance.
por: Maria Cristina Thaller, et al.
Publicado: (2010)