Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA.

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Autores principales:	Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson, Patrick Calsou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ae106c908e2492dbfe13e901e7a9e12
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spelling	oai:doaj.org-article:3ae106c908e2492dbfe13e901e7a9e122021-12-02T15:35:42ZCoordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks10.1038/ncomms128892041-1723https://doaj.org/article/3ae106c908e2492dbfe13e901e7a9e122016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12889https://doaj.org/toc/2041-1723Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA.Pauline ChanutSébastien BrittonJulia CoatesStephen P. JacksonPatrick CalsouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pauline Chanut Sébastien Britton Julia Coates Stephen P. Jackson Patrick Calsou Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
description	Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA.
format	article
author	Pauline Chanut Sébastien Britton Julia Coates Stephen P. Jackson Patrick Calsou
author_facet	Pauline Chanut Sébastien Britton Julia Coates Stephen P. Jackson Patrick Calsou
author_sort	Pauline Chanut
title	Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
title_short	Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
title_full	Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
title_fullStr	Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
title_full_unstemmed	Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
title_sort	coordinated nuclease activities counteract ku at single-ended dna double-strand breaks
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3ae106c908e2492dbfe13e901e7a9e12
work_keys_str_mv	AT paulinechanut coordinatednucleaseactivitiescounteractkuatsingleendeddnadoublestrandbreaks AT sebastienbritton coordinatednucleaseactivitiescounteractkuatsingleendeddnadoublestrandbreaks AT juliacoates coordinatednucleaseactivitiescounteractkuatsingleendeddnadoublestrandbreaks AT stephenpjackson coordinatednucleaseactivitiescounteractkuatsingleendeddnadoublestrandbreaks AT patrickcalsou coordinatednucleaseactivitiescounteractkuatsingleendeddnadoublestrandbreaks
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Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

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