Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA.

Guardado en:
Detalles Bibliográficos
Autores principales: Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson, Patrick Calsou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3ae106c908e2492dbfe13e901e7a9e12
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares