CRISPR technologies and the search for the PAM-free nuclease

One of the key limitations of CRISPR-Cas-based genome editing techniques is the PAM dependency. Here, the authors review ongoing efforts towards realizing PAM-free nucleases, address potential consequences of eliminating PAM recognition, and propose an alternative nuclease repertoire covering all po...

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Autores principales: Daphne Collias, Chase L. Beisel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3b0005fc19784851be7b5e4a5d35393a
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