Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d20 |
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