Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d20 |
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| Sumario: | Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile toxins and the resistance of the binders to acid, digestive proteases and heat. |
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