Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid

Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile...

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Autores principales:	Niels Wicke, Mike R. Bedford, Mark Howarth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d20
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spelling	oai:doaj.org-article:3b08a71c400e4aa89074465f0cb87d202021-12-02T16:43:38ZGastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid10.1038/s42003-021-02487-22399-3642https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d202021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02487-2https://doaj.org/toc/2399-3642Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile toxins and the resistance of the binders to acid, digestive proteases and heat.Niels WickeMike R. BedfordMark HowarthNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Niels Wicke Mike R. Bedford Mark Howarth Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
description	Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile toxins and the resistance of the binders to acid, digestive proteases and heat.
format	article
author	Niels Wicke Mike R. Bedford Mark Howarth
author_facet	Niels Wicke Mike R. Bedford Mark Howarth
author_sort	Niels Wicke
title	Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
title_short	Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
title_full	Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
title_fullStr	Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
title_full_unstemmed	Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
title_sort	gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d20
work_keys_str_mv	AT nielswicke gastrobodiesareengineeredantibodymimeticsresilienttopepsinandhydrochloricacid AT mikerbedford gastrobodiesareengineeredantibodymimeticsresilienttopepsinandhydrochloricacid AT markhowarth gastrobodiesareengineeredantibodymimeticsresilienttopepsinandhydrochloricacid
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Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid

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