Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid

Wicke, Bedford & Howarth present a protein engineering strategy focusing on the survival of protein targeting reagents in the GI tract. For this, they engineer a Kunitz soybean trypsin inhibitor as the scaffold and showcase the binding of the engineered antibody mimetics to Clostridium difficile...

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Autores principales: Niels Wicke, Mike R. Bedford, Mark Howarth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3b08a71c400e4aa89074465f0cb87d20
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