The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.

<h4>Background</h4>Hypertonicity can perturb cellular functions, induce DNA damage-like responses and inhibit proliferation. The transcription factor NFAT5 induces osmoprotective gene products that allow cells to adapt to sustained hypertonic conditions. Although it is known that NFAT5-d...

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Autores principales: Katherine Drews-Elger, M Carmen Ortells, Anjana Rao, Cristina López-Rodriguez, Jose Aramburu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/3b08b906199040358b5efac7ba4ed48a
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