Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of proapoptotic protein, Bim.

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Autores principales:	Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b2da2db381e4fd0ae6f0d0669ca275b
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spelling	oai:doaj.org-article:3b2da2db381e4fd0ae6f0d0669ca275b2021-12-02T16:06:03ZSpermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression10.1038/s41467-020-17067-x2041-1723https://doaj.org/article/3b2da2db381e4fd0ae6f0d0669ca275b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17067-xhttps://doaj.org/toc/2041-1723Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of proapoptotic protein, Bim.Yubin GuoQing YePan DengYanan CaoDaheng HeZhaohe ZhouChi WangYekaterina Y. ZaytsevaCharles E. SchwartzEun Y. LeeB. Mark EversAndrew J. MorrisSide LiuQing-Bai SheNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yubin Guo Qing Ye Pan Deng Yanan Cao Daheng He Zhaohe Zhou Chi Wang Yekaterina Y. Zaytseva Charles E. Schwartz Eun Y. Lee B. Mark Evers Andrew J. Morris Side Liu Qing-Bai She Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
description	Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of proapoptotic protein, Bim.
format	article
author	Yubin Guo Qing Ye Pan Deng Yanan Cao Daheng He Zhaohe Zhou Chi Wang Yekaterina Y. Zaytseva Charles E. Schwartz Eun Y. Lee B. Mark Evers Andrew J. Morris Side Liu Qing-Bai She
author_facet	Yubin Guo Qing Ye Pan Deng Yanan Cao Daheng He Zhaohe Zhou Chi Wang Yekaterina Y. Zaytseva Charles E. Schwartz Eun Y. Lee B. Mark Evers Andrew J. Morris Side Liu Qing-Bai She
author_sort	Yubin Guo
title	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
title_short	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
title_full	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
title_fullStr	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
title_full_unstemmed	Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
title_sort	spermine synthase and myc cooperate to maintain colorectal cancer cell survival by repressing bim expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b2da2db381e4fd0ae6f0d0669ca275b
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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

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