Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

Multidrug resistance necessitates novel approaches to treating bacterial infections. Here, the authors apply their high-throughput screening and in silico prediction approaches to show that host receptor tyrosine kinases are good targets for host-directed therapies against intracellular bacteria.

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Autores principales:	Cornelis J. Korbee, Matthias T. Heemskerk, Dragi Kocev, Elisabeth van Strijen, Omid Rabiee, Kees L. M. C. Franken, Louis Wilson, Nigel D. L. Savage, Sašo Džeroski, Mariëlle C. Haks, Tom H. M. Ottenhoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b316921c3c14158967dd51b494a3bc2
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spelling	oai:doaj.org-article:3b316921c3c14158967dd51b494a3bc22021-12-02T14:38:48ZCombined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials10.1038/s41467-017-02777-62041-1723https://doaj.org/article/3b316921c3c14158967dd51b494a3bc22018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02777-6https://doaj.org/toc/2041-1723Multidrug resistance necessitates novel approaches to treating bacterial infections. Here, the authors apply their high-throughput screening and in silico prediction approaches to show that host receptor tyrosine kinases are good targets for host-directed therapies against intracellular bacteria.Cornelis J. KorbeeMatthias T. HeemskerkDragi KocevElisabeth van StrijenOmid RabieeKees L. M. C. FrankenLouis WilsonNigel D. L. SavageSašo DžeroskiMariëlle C. HaksTom H. M. OttenhoffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cornelis J. Korbee Matthias T. Heemskerk Dragi Kocev Elisabeth van Strijen Omid Rabiee Kees L. M. C. Franken Louis Wilson Nigel D. L. Savage Sašo Džeroski Mariëlle C. Haks Tom H. M. Ottenhoff Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
description	Multidrug resistance necessitates novel approaches to treating bacterial infections. Here, the authors apply their high-throughput screening and in silico prediction approaches to show that host receptor tyrosine kinases are good targets for host-directed therapies against intracellular bacteria.
format	article
author	Cornelis J. Korbee Matthias T. Heemskerk Dragi Kocev Elisabeth van Strijen Omid Rabiee Kees L. M. C. Franken Louis Wilson Nigel D. L. Savage Sašo Džeroski Mariëlle C. Haks Tom H. M. Ottenhoff
author_facet	Cornelis J. Korbee Matthias T. Heemskerk Dragi Kocev Elisabeth van Strijen Omid Rabiee Kees L. M. C. Franken Louis Wilson Nigel D. L. Savage Sašo Džeroski Mariëlle C. Haks Tom H. M. Ottenhoff
author_sort	Cornelis J. Korbee
title	Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
title_short	Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
title_full	Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
title_fullStr	Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
title_full_unstemmed	Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
title_sort	combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3b316921c3c14158967dd51b494a3bc2
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Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

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