IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK

Abstract Head and neck cancer is the sixth most common cancer worldwide with a 5-year survival of only 65%. Targeting compensatory signaling pathways may improve therapeutic responses and combat resistance. Utilizing reverse phase protein arrays (RPPA) to assess the proteome and explore mechanisms o...

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Autores principales: Christine E. Lehman, Adam Spencer, Sarah Hall, Jeremy J. P. Shaw, Julia Wulfkuhle, Emanuel F. Petricoin, Stefan Bekiranov, Mark J. Jameson, Daniel Gioeli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3b347bf831e74651bf20811b8511fc1e
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