MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

Reprogramming of mitochondria metabolism occurs during naïve to primed pluripotency differentiation in mouse embryonic stem cells (ESCs). Here the authors show that mitochondrial MTCH2 regulates mitochondrial fusion and that this fusion is required for naïve to primed pluripotency conversion

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Autores principales: Amir Bahat, Andres Goldman, Yehudit Zaltsman, Dilshad H. Khan, Coral Halperin, Emmanuel Amzallag, Vladislav Krupalnik, Michael Mullokandov, Alon Silberman, Ayelet Erez, Aaron D. Schimmer, Jacob H. Hanna, Atan Gross
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/3b42662e2cea47e7be6870e3d559ad27
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https://doaj.org/article/3b42662e2cea47e7be6870e3d559ad27

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