Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells

Abstract Surgery and radiotherapy cannot fully remove brain glioma; thus, chemotherapy continues to play an important role in treatment of this illness. However, because of the restriction of the blood-brain barrier (BBB) and the regeneration of glioma stem cells, post-chemotherapy relapse usually o...

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Autores principales:	Li-Min Mu, Ying-Zi Bu, Lei Liu, Hong-Jun Xie, Rui-Jun Ju, Jia-Shuan Wu, Fan Zeng, Yao Zhao, Jing-Ying Zhang, Wan-Liang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3b4ad1d8fd21474e988947e08319834e
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spelling	oai:doaj.org-article:3b4ad1d8fd21474e988947e08319834e2021-12-02T15:05:20ZLipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells10.1038/s41598-017-03805-72045-2322https://doaj.org/article/3b4ad1d8fd21474e988947e08319834e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03805-7https://doaj.org/toc/2045-2322Abstract Surgery and radiotherapy cannot fully remove brain glioma; thus, chemotherapy continues to play an important role in treatment of this illness. However, because of the restriction of the blood-brain barrier (BBB) and the regeneration of glioma stem cells, post-chemotherapy relapse usually occurs. Here, we report a potential solution to these issues that involves a type of novel multifunctional vinblastine liposomes equipped with transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8. Studies were performed on brain glioma and glioma stem cells in vitro and were verified in brain glioma-bearing mice. The liposomes were transported across the BBB, killing brain glioma and glioma stem cells via the induction of necrosis, apoptosis and autophagy. Furthermore, we reveal the molecular mechanisms for treating brain glioma and glioma stem cells via functionalized drug lipid vesicles.Li-Min MuYing-Zi BuLei LiuHong-Jun XieRui-Jun JuJia-Shuan WuFan ZengYao ZhaoJing-Ying ZhangWan-Liang LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Min Mu Ying-Zi Bu Lei Liu Hong-Jun Xie Rui-Jun Ju Jia-Shuan Wu Fan Zeng Yao Zhao Jing-Ying Zhang Wan-Liang Lu Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
description	Abstract Surgery and radiotherapy cannot fully remove brain glioma; thus, chemotherapy continues to play an important role in treatment of this illness. However, because of the restriction of the blood-brain barrier (BBB) and the regeneration of glioma stem cells, post-chemotherapy relapse usually occurs. Here, we report a potential solution to these issues that involves a type of novel multifunctional vinblastine liposomes equipped with transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8. Studies were performed on brain glioma and glioma stem cells in vitro and were verified in brain glioma-bearing mice. The liposomes were transported across the BBB, killing brain glioma and glioma stem cells via the induction of necrosis, apoptosis and autophagy. Furthermore, we reveal the molecular mechanisms for treating brain glioma and glioma stem cells via functionalized drug lipid vesicles.
format	article
author	Li-Min Mu Ying-Zi Bu Lei Liu Hong-Jun Xie Rui-Jun Ju Jia-Shuan Wu Fan Zeng Yao Zhao Jing-Ying Zhang Wan-Liang Lu
author_facet	Li-Min Mu Ying-Zi Bu Lei Liu Hong-Jun Xie Rui-Jun Ju Jia-Shuan Wu Fan Zeng Yao Zhao Jing-Ying Zhang Wan-Liang Lu
author_sort	Li-Min Mu
title	Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
title_short	Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
title_full	Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
title_fullStr	Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
title_full_unstemmed	Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
title_sort	lipid vesicles containing transferrin receptor binding peptide tfr-t12 and octa-arginine conjugate stearyl-r8 efficiently treat brain glioma along with glioma stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b4ad1d8fd21474e988947e08319834e
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Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells

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