Oxidation-specific epitopes restrain bone formation

Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced...

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Bibliographic Details
Main Authors: Elena Ambrogini, Xuchu Que, Shuling Wang, Fumihiro Yamaguchi, Robert S. Weinstein, Sotirios Tsimikas, Stavros C. Manolagas, Joseph L. Witztum, Robert L. Jilka
Format: article
Language:EN
Published: Nature Portfolio 2018
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Q
Online Access:https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6
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