Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

When examining the evolution of treatment resistance in breast cancer, perceived genomic changes may be due to clonal evolution or heterogeneous tumors. Here, the authors show that apparent clonal change can in fact be due to pre-treatment heterogeneity, and samples from at least two regions are nec...

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Autores principales:	Jennifer L. Caswell-Jin, Katherine McNamara, Johannes G. Reiter, Ruping Sun, Zheng Hu, Zhicheng Ma, Jie Ding, Carlos J. Suarez, Susanne Tilk, Akshara Raghavendra, Victoria Forte, Suet-Feung Chin, Helen Bardwell, Elena Provenzano, Carlos Caldas, Julie Lang, Robert West, Debu Tripathy, Michael F. Press, Christina Curtis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b5c30a996d54c2086cfff5a285a1014
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spelling	oai:doaj.org-article:3b5c30a996d54c2086cfff5a285a10142021-12-02T17:02:08ZClonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy10.1038/s41467-019-08593-42041-1723https://doaj.org/article/3b5c30a996d54c2086cfff5a285a10142019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08593-4https://doaj.org/toc/2041-1723When examining the evolution of treatment resistance in breast cancer, perceived genomic changes may be due to clonal evolution or heterogeneous tumors. Here, the authors show that apparent clonal change can in fact be due to pre-treatment heterogeneity, and samples from at least two regions are necessary to detect treatment-induced clonal shiftsJennifer L. Caswell-JinKatherine McNamaraJohannes G. ReiterRuping SunZheng HuZhicheng MaJie DingCarlos J. SuarezSusanne TilkAkshara RaghavendraVictoria ForteSuet-Feung ChinHelen BardwellElena ProvenzanoCarlos CaldasJulie LangRobert WestDebu TripathyMichael F. PressChristina CurtisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer L. Caswell-Jin Katherine McNamara Johannes G. Reiter Ruping Sun Zheng Hu Zhicheng Ma Jie Ding Carlos J. Suarez Susanne Tilk Akshara Raghavendra Victoria Forte Suet-Feung Chin Helen Bardwell Elena Provenzano Carlos Caldas Julie Lang Robert West Debu Tripathy Michael F. Press Christina Curtis Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
description	When examining the evolution of treatment resistance in breast cancer, perceived genomic changes may be due to clonal evolution or heterogeneous tumors. Here, the authors show that apparent clonal change can in fact be due to pre-treatment heterogeneity, and samples from at least two regions are necessary to detect treatment-induced clonal shifts
format	article
author	Jennifer L. Caswell-Jin Katherine McNamara Johannes G. Reiter Ruping Sun Zheng Hu Zhicheng Ma Jie Ding Carlos J. Suarez Susanne Tilk Akshara Raghavendra Victoria Forte Suet-Feung Chin Helen Bardwell Elena Provenzano Carlos Caldas Julie Lang Robert West Debu Tripathy Michael F. Press Christina Curtis
author_facet	Jennifer L. Caswell-Jin Katherine McNamara Johannes G. Reiter Ruping Sun Zheng Hu Zhicheng Ma Jie Ding Carlos J. Suarez Susanne Tilk Akshara Raghavendra Victoria Forte Suet-Feung Chin Helen Bardwell Elena Provenzano Carlos Caldas Julie Lang Robert West Debu Tripathy Michael F. Press Christina Curtis
author_sort	Jennifer L. Caswell-Jin
title	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
title_short	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
title_full	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
title_fullStr	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
title_full_unstemmed	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
title_sort	clonal replacement and heterogeneity in breast tumors treated with neoadjuvant her2-targeted therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3b5c30a996d54c2086cfff5a285a1014
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Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

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