The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Johanna Grinat, Julian Heuberger, Ramon Oliveira Vidal, Neha Goveas, Frauke Kosel, Antoni Berenguer-Llergo, Andrea Kranz, Annika Wulf-Goldenberg, Diana Behrens, Bálint Melcher, Sascha Sauer, Michael Vieth, Eduard Batlle, A. Francis Stewart, Walter Birchmeier
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Q
Accès en ligne:https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!