The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.

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Autores principales:	Johanna Grinat, Julian Heuberger, Ramon Oliveira Vidal, Neha Goveas, Frauke Kosel, Antoni Berenguer-Llergo, Andrea Kranz, Annika Wulf-Goldenberg, Diana Behrens, Bálint Melcher, Sascha Sauer, Michael Vieth, Eduard Batlle, A. Francis Stewart, Walter Birchmeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
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spelling	oai:doaj.org-article:3b5f2ff3d1124d7c81f483c2f20a5a382021-12-02T13:57:55ZThe epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness10.1038/s41467-020-20222-z2041-1723https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a382020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20222-zhttps://doaj.org/toc/2041-1723Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.Johanna GrinatJulian HeubergerRamon Oliveira VidalNeha GoveasFrauke KoselAntoni Berenguer-LlergoAndrea KranzAnnika Wulf-GoldenbergDiana BehrensBálint MelcherSascha SauerMichael ViethEduard BatlleA. Francis StewartWalter BirchmeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
description	Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
format	article
author	Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier
author_facet	Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier
author_sort	Johanna Grinat
title	The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
title_short	The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
title_full	The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
title_fullStr	The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
title_full_unstemmed	The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
title_sort	epigenetic regulator mll1 is required for wnt-driven intestinal tumorigenesis and cancer stemness
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
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The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

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