Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer

The detailed folding mechanisms of membrane proteins in their natural bilayer-like environments remains poorly understood due to the lack of tools for measuring stabilities and kinetics. Here, by simulating the folding of GlpG in a bilayer, the authors provide support for the helical-hairpin hypothe...

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Autores principales: Wei Lu, Nicholas P. Schafer, Peter G. Wolynes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3b629c330a4c40749ac3167daefde321
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