Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer

The detailed folding mechanisms of membrane proteins in their natural bilayer-like environments remains poorly understood due to the lack of tools for measuring stabilities and kinetics. Here, by simulating the folding of GlpG in a bilayer, the authors provide support for the helical-hairpin hypothe...

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Autores principales:	Wei Lu, Nicholas P. Schafer, Peter G. Wolynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b629c330a4c40749ac3167daefde321
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spelling	oai:doaj.org-article:3b629c330a4c40749ac3167daefde3212021-12-02T16:50:11ZEnergy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer10.1038/s41467-018-07320-92041-1723https://doaj.org/article/3b629c330a4c40749ac3167daefde3212018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07320-9https://doaj.org/toc/2041-1723The detailed folding mechanisms of membrane proteins in their natural bilayer-like environments remains poorly understood due to the lack of tools for measuring stabilities and kinetics. Here, by simulating the folding of GlpG in a bilayer, the authors provide support for the helical-hairpin hypothesis and prompt a re-evaluation of a long-standing paradigm, the two-stage hypothesis.Wei LuNicholas P. SchaferPeter G. WolynesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Lu Nicholas P. Schafer Peter G. Wolynes Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
description	The detailed folding mechanisms of membrane proteins in their natural bilayer-like environments remains poorly understood due to the lack of tools for measuring stabilities and kinetics. Here, by simulating the folding of GlpG in a bilayer, the authors provide support for the helical-hairpin hypothesis and prompt a re-evaluation of a long-standing paradigm, the two-stage hypothesis.
format	article
author	Wei Lu Nicholas P. Schafer Peter G. Wolynes
author_facet	Wei Lu Nicholas P. Schafer Peter G. Wolynes
author_sort	Wei Lu
title	Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
title_short	Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
title_full	Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
title_fullStr	Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
title_full_unstemmed	Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
title_sort	energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3b629c330a4c40749ac3167daefde321
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Energy landscape underlying spontaneous insertion and folding of an alpha-helical transmembrane protein into a bilayer

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