Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit

Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer immunotherapy. In this study, we found that the intratumo...

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Bibliographic Details
Main Authors:	Hua Yu, Ying Bai, Jing Qiu, Xiaomei He, Junzhi Xiong, Qian Dai, Xingmin Wang, Yuanyuan Li, Halei Sheng, Rong Xin, Lu Jiang, Qiaoqiao Li, Defeng Li, Hong Zhang, Le Zhang, Qian Chen, Jin Peng, Xiaomei Hu, Kebin Zhang
Format:	article
Language:	EN
Published:	Frontiers Media S.A. 2021
Subjects:	Pseudomonas aeruginosa PcrV protein TAM reeducation tumoricidal efficacy TLR4/PI3K/AKT/mTOR-glycolysis-NO feedback loop PcrV–TLR4 interaction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Online Access:	https://doaj.org/article/3b6f24f61d9f48d5acc98567f852e72c
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Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit

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