Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival
ABSTRACT Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-mediated immunity, resulting in fulm...
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| Main Authors: | , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/3b8ad016c6e6453b88c18d169d66bf18 |
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