Targeting glutamine metabolism slows soft tissue sarcoma growth

Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors show that soft tissue sarcomas expressing high levels of glutaminase (GLS) are particularly sensitive to glutamine starvation and GLS inhibition in tumour-bearing allograft and autochthonous mouse mode...

Full description

Saved in:
Bibliographic Details
Main Authors: Pearl Lee, Dania Malik, Nicholas Perkons, Peiwei Huangyang, Sanika Khare, Seth Rhoades, Yao-Yu Gong, Michelle Burrows, Jennifer M. Finan, Itzhak Nissim, Terence P. F. Gade, Aalim M. Weljie, M. Celeste Simon
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/3b907274e9ce47de86b2c4ff4f6b6ad0
Tags: Add Tag
No Tags, Be the first to tag this record!