A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical...

Full description

Saved in:
Bibliographic Details
Main Authors: J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/3b9f916136964f4eb118797ed067be1e
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/3b9f916136964f4eb118797ed067be1e

Similar Items