Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion i...
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Nature Portfolio
2019
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oai:doaj.org-article:3ba71f4e4b844e449ec46f1e2075895f2021-12-02T14:38:40ZPharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis10.1038/s41467-018-08129-22041-1723https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08129-2https://doaj.org/toc/2041-1723Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.Erik A. BlackwoodKhalid AziziDonna J. ThueraufRyan J. PaxmanLars PlateJeffery W. KellyR. Luke WisemanChristopher C. GlembotskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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Science Q Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
description |
Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney. |
format |
article |
author |
Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski |
author_facet |
Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski |
author_sort |
Erik A. Blackwood |
title |
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
title_short |
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
title_full |
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
title_fullStr |
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
title_full_unstemmed |
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
title_sort |
pharmacologic atf6 activation confers global protection in widespread disease models by reprograming cellular proteostasis |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f |
work_keys_str_mv |
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