Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion i...

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Autores principales: Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf, Ryan J. Paxman, Lars Plate, Jeffery W. Kelly, R. Luke Wiseman, Christopher C. Glembotski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
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spelling oai:doaj.org-article:3ba71f4e4b844e449ec46f1e2075895f2021-12-02T14:38:40ZPharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis10.1038/s41467-018-08129-22041-1723https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08129-2https://doaj.org/toc/2041-1723Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.Erik A. BlackwoodKhalid AziziDonna J. ThueraufRyan J. PaxmanLars PlateJeffery W. KellyR. Luke WisemanChristopher C. GlembotskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Erik A. Blackwood
Khalid Azizi
Donna J. Thuerauf
Ryan J. Paxman
Lars Plate
Jeffery W. Kelly
R. Luke Wiseman
Christopher C. Glembotski
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
description Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.
format article
author Erik A. Blackwood
Khalid Azizi
Donna J. Thuerauf
Ryan J. Paxman
Lars Plate
Jeffery W. Kelly
R. Luke Wiseman
Christopher C. Glembotski
author_facet Erik A. Blackwood
Khalid Azizi
Donna J. Thuerauf
Ryan J. Paxman
Lars Plate
Jeffery W. Kelly
R. Luke Wiseman
Christopher C. Glembotski
author_sort Erik A. Blackwood
title Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_short Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_full Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_fullStr Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_full_unstemmed Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_sort pharmacologic atf6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
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AT khalidazizi pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT donnajthuerauf pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT ryanjpaxman pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT larsplate pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT jefferywkelly pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT rlukewiseman pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
AT christophercglembotski pharmacologicatf6activationconfersglobalprotectioninwidespreaddiseasemodelsbyreprogramingcellularproteostasis
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