Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion i...

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Main Authors:	Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf, Ryan J. Paxman, Lars Plate, Jeffery W. Kelly, R. Luke Wiseman, Christopher C. Glembotski
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
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spelling	oai:doaj.org-article:3ba71f4e4b844e449ec46f1e2075895f2021-12-02T14:38:40ZPharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis10.1038/s41467-018-08129-22041-1723https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08129-2https://doaj.org/toc/2041-1723Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.Erik A. BlackwoodKhalid AziziDonna J. ThueraufRyan J. PaxmanLars PlateJeffery W. KellyR. Luke WisemanChristopher C. GlembotskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
description	Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.
format	article
author	Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski
author_facet	Erik A. Blackwood Khalid Azizi Donna J. Thuerauf Ryan J. Paxman Lars Plate Jeffery W. Kelly R. Luke Wiseman Christopher C. Glembotski
author_sort	Erik A. Blackwood
title	Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_short	Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_full	Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_fullStr	Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_full_unstemmed	Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
title_sort	pharmacologic atf6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3ba71f4e4b844e449ec46f1e2075895f
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Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

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