Real-time observation of polymerase-promoter contact remodeling during transcription initiation

Contacts between RNA polymerase and promoter DNA modulate the strength of binding and the frequency of promoter escape during transcription. Here, the authors describe a single molecule optical-trapping assay to study transcription initiation and observe the dynamic remodeling of enzyme contacts in...

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Autores principales: Cong A. Meng, Furqan M. Fazal, Steven M. Block
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3bd3119120af44ce91cb96c3a3fcba13
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