Real-time observation of polymerase-promoter contact remodeling during transcription initiation

Contacts between RNA polymerase and promoter DNA modulate the strength of binding and the frequency of promoter escape during transcription. Here, the authors describe a single molecule optical-trapping assay to study transcription initiation and observe the dynamic remodeling of enzyme contacts in...

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Autores principales:	Cong A. Meng, Furqan M. Fazal, Steven M. Block
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bd3119120af44ce91cb96c3a3fcba13
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spelling	oai:doaj.org-article:3bd3119120af44ce91cb96c3a3fcba132021-12-02T14:40:23ZReal-time observation of polymerase-promoter contact remodeling during transcription initiation10.1038/s41467-017-01041-12041-1723https://doaj.org/article/3bd3119120af44ce91cb96c3a3fcba132017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01041-1https://doaj.org/toc/2041-1723Contacts between RNA polymerase and promoter DNA modulate the strength of binding and the frequency of promoter escape during transcription. Here, the authors describe a single molecule optical-trapping assay to study transcription initiation and observe the dynamic remodeling of enzyme contacts in real time.Cong A. MengFurqan M. FazalSteven M. BlockNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cong A. Meng Furqan M. Fazal Steven M. Block Real-time observation of polymerase-promoter contact remodeling during transcription initiation
description	Contacts between RNA polymerase and promoter DNA modulate the strength of binding and the frequency of promoter escape during transcription. Here, the authors describe a single molecule optical-trapping assay to study transcription initiation and observe the dynamic remodeling of enzyme contacts in real time.
format	article
author	Cong A. Meng Furqan M. Fazal Steven M. Block
author_facet	Cong A. Meng Furqan M. Fazal Steven M. Block
author_sort	Cong A. Meng
title	Real-time observation of polymerase-promoter contact remodeling during transcription initiation
title_short	Real-time observation of polymerase-promoter contact remodeling during transcription initiation
title_full	Real-time observation of polymerase-promoter contact remodeling during transcription initiation
title_fullStr	Real-time observation of polymerase-promoter contact remodeling during transcription initiation
title_full_unstemmed	Real-time observation of polymerase-promoter contact remodeling during transcription initiation
title_sort	real-time observation of polymerase-promoter contact remodeling during transcription initiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3bd3119120af44ce91cb96c3a3fcba13
work_keys_str_mv	AT congameng realtimeobservationofpolymerasepromotercontactremodelingduringtranscriptioninitiation AT furqanmfazal realtimeobservationofpolymerasepromotercontactremodelingduringtranscriptioninitiation AT stevenmblock realtimeobservationofpolymerasepromotercontactremodelingduringtranscriptioninitiation
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Real-time observation of polymerase-promoter contact remodeling during transcription initiation

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